Hydrochloric Acid → 5-Amino-1-(2-hydroxyethyl)-4-nitrosopyrazole hydrochloride

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a flask having an inner volume of 200 ml and equipped with a stirring device, a thermometer and a reflux condenser were charged 16.86 g (110 mmol) of 3,3-dimethoxy-2-hydroxyiminopropionitrile with a purity of 94.0% by weight synthesized in the same manner as in Example. 1, 8.02 g (100 mmol) of 2-hydroxyethylhydrazine with a purity of 95% by weight, 100 ml of ethanol and 10 ml (120 mmol) of conc. hydrochloric acid, and the mixture was reacted under reflux (76 to 77° C.) for one hour. After completion of the reaction, when the reaction mixture was analyzed by high performance liquid chromatography (absolute calibration curve method), it was found that 17.62 g of 5-amino-1-(2-hydroxyethyl)-4-nitrosopyrazole hydrochloride (Reaction yield: 91.5%) had been formed.

Herkunft & Nachweise