HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Chloroaniline → 3-(4-Chlorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Chloroaniline | HCID 7812 | — |
| Edukt | Ethyl orthoformate | HCID 31214 | — |
| Edukt | Methyl 3-amino-4-phenylthiophene-2-carboxylate | HCID 2759782 | — |
| Edukt | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Produkt | 3-(4-Chlorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324871 | 36% |
Reaktionsschritte
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (60 mg, 0.26 mmol), triethyl orthoformate (0.5 ml), 4-chloroaniline (61 mg, 0.48 mmol), and acetic acid (0.06 ml) were used to give 31.6 mg (0.093 mmol, 36% yield) of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09260448B2 |
| Quelldatensatz | uspto-grants-2016_02 |
| ORD ID | ord-5a958cc719064c4fa99885c901bb0df5 |
| Quellennotiz | uspto-grants-2016_02 |