HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → 1-Benzyl-6-fluoro-4-piperidin-4-yl-1H-indole-2-carboxylic acid amide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | Trifluoroacetate | HCID 84468 | — |
| Edukt | 4-(1-Benzyl-2-carbamoyl-6-fluoro-1H-indol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester | HCID 68586044 | — |
| Produkt | 1-Benzyl-6-fluoro-4-piperidin-4-yl-1H-indole-2-carboxylic acid amide | HCID 24953072 | — |
Reaktionsschritte
1-Benzyl-6-fluoro-4-piperidin-4-yl-1H-indole-2-carboxylic acid amide was prepared as trifluoroacetate salt by hydrogenation of 4-(1-Benzyl-2-carbamoyl-6-fluoro-1H-indol-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester, followed by deprotection with trifluoroacetic acid, using the procedure of steps 3 and 4 of Example 2. MS: (M+H)+ 352.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07741326B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-b950e1b62e0048149a0aa87dc89f4bd1 |
| Quellennotiz | uspto-grants-2010_06 |