HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethanol → 2-Ethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethanol | HCID 702 | — |
| Edukt | 1-Bromo-2-butanone | HCID 13156 | — |
| Edukt | 2-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyrazine | HCID 14719928 | — |
| Katalysator | Adams' catalyst | HCID 345198 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 2-Ethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine | HCID 14719929 | — |
Reaktionsschritte
2-Ethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine was prepared in an analogous manner to that described above for 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (Intermediate 4) but starting from 1-bromo-2-butanone instead of 3-bromo-1,1,1-trifluoro-2-propanone and using platinum (IV) oxide and ethanol in the place of 10% palladium on carbon paste and methanol for the hydrogenation step.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08513248B2 |
| Quelldatensatz | uspto-grants-2013_08 |
| ORD ID | ord-dc83d8cd0490483da8ea4fa3c7072d4e |
| Quellennotiz | uspto-grants-2013_08 |