HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Thiosemicarbazide → N-Ethyl-N-[3-(3-amino-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]propanamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Thiosemicarbazide | HCID 2723789 | — |
| Edukt | N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide | HCID 14280299 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | N-Ethyl-N-[3-(3-amino-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]propanamide | HCID 15595696 | 44,8% |
Reaktionsschritte
A solution of 5.0 g N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide and 3.2 g thiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was treated and the product chromatographed as described for Example 70. Recrystalization of the product from dichloromethane-hexane afforded 2.4 g yellow crystals, mp 199°-200° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04654343 |
| Quelldatensatz | uspto-grants-1987_03 |
| ORD ID | ord-2be52cf7f9bc4df9be7fe5307c8cc9e4 |
| Quellennotiz | uspto-grants-1987_03 |