HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Toluene → (E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Toluene | HCID 1140 | — |
| Edukt | Carboxymethylene triphenylphosphorane | HCID 10870911 | — |
| Edukt | 5-Hydroxy-[1,1'-biphenyl]-2-carbaldehyde | HCID 57303464 | — |
| Produkt | (E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylate | HCID 58566652 | — |
Reaktionsschritte
A solution of 5-hydroxy-[1,1′-biphenyl]-2-carbaldehyde (651) (292 mg, 1.47 mmol) and (carboxymethylene)-triphenylphosphorane (564.5 mg, 1.62 mmol) in toluene (15 mL) was refluxed for 24 hours. The reaction was concentrated in vacuo and was purified by flash column chromatography on silica gel with hexanes and EtOAc (30%) to give (E)-ethyl 3-(5-hydroxy-[1,1′-biphenyl]-2-yl)acrylate (652).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08598374B2 |
| Quelldatensatz | uspto-grants-2013_12 |
| ORD ID | ord-fbe773790a124d9987d1933f8f5716e3 |
| Quellennotiz | uspto-grants-2013_12 |