Hydrochloric Acid → 4,6-Dimethyl-2(1H)-pyrimidinone hydrochloride

HRID 1910805

Reaktionsgleichung

Reaktionsgleichung von HRID 1910805
[C:1]([CH2:4][C:5](=O)[CH3:6])(=O)[CH3:2].[NH2:8][C:9]([NH2:11])=[O:10].[ClH:12]>C(O)C>[ClH:12].[CH3:2][C:1]1[CH:4]=[C:5]([CH3:6])[NH:11][C:9](=[O:10])[N:8]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 1176UreaHCID 31261Acetylacetone

Produkt 1

HCID 123431664,6-Dimethyl-2(1H)-pyrimidinone hydrochlorideAusbeute 55 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a mixture of acetyl acetone (4.0 g, 40.0 mmol) and urea (2.0 g, 33.3 mmol) in ethanol (40 mL) was added concentrated HCl (10 mL) and stirred at reflux for 3 h. The reaction mixture was cooled to 0° C. and filtered; the colourless solid was washed thoroughly with ice cold ethanol then ether and dried under vacuum to afford 4,6-dimethyl-1H-pyrimidin-2-one hydrochloride (3.5 g, 55%) as a solid.

Aufarbeitung

  1. temperatureat reflux for 3 h
  2. filtrationfiltered
  3. washthe colourless solid was washed thoroughly with ice cold ethanol
  4. dry with materialether and dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-491904216b374f63a45fd8b8a8d40266
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08604029B2

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