HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → 4-(4-Chloro-phenyl)-6-cyclopropyl-2-(4-pyridin-3-yl-imidazol-1-yl)-pyrimidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | HCID 2734656 | — |
| Edukt | 2-(4-Bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-cyclopropyl-pyrimidine | HCID 57468738 | — |
| Produkt | 4-(4-Chloro-phenyl)-6-cyclopropyl-2-(4-pyridin-3-yl-imidazol-1-yl)-pyrimidine | HCID 57468864 | — |
Reaktionsschritte
The title compound was prepared from 2-(4-bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-cyclopropyl-pyrimidine (example E.14) (0.15 g, 0.4 mmol) and commercially available 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (0.08 g, 0.4 mmol) according to the general procedure VI. Obtained as an off-white solid (0.015 g, 10%). MS (ISP) 374.0 [(M+H)+]; mp 180-182° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08183262B2 |
| Quelldatensatz | uspto-grants-2012_05 |
| ORD ID | ord-3eacac7735f649af9f5944c8c7137c9a |
| Quellennotiz | uspto-grants-2012_05 |