Potassium Carbonate → HCID 69323150, Verbindung

Beteiligte Stoffe

Reaktionsschritte

The title compound was prepared from iodomethyl 2-(methyl)ethyl carbonate (92 mg, 0.354 mmol), (4aS,13aR)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazine-8-carboxamide sodium salt (80 mg, 0.177 mmol), potassium carbonate (73 mg, 0.531 mmol), and tetrabutylammonium hydrogen sulfate (60 mg, 0.177 mmol), using a similar process to that described in example 1. 1H NMR (CDCl3) δ 10.23 (m, 1 H), 8.39 (s, 1 H), 7.30 (m, 1 H), 6.77 (m, 2 H), 5.89 (d, J=6.4 Hz, 1 H), 5.78 (d, J=6.4 Hz, 1 H), 4.56-4.48 (m, 3 H), 4.34-4.15 (m, 4 H), 3.86 (m, 1 H), 3.69-3.55 (m, 3 H), 3.31 (s, 3 H), 3.11-2.95 (m, 2 H), 2.78 (m, 1 H), 2.04-1.84 (m, 3 H), 1.63 (m, 1 H). ES+ MS: 563 (M+1).

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