HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,4-Dibromo-2-butanol → cis-N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,4-Dibromo-2-butanol | HCID 29570 | — |
| Edukt | cis-N-(2-Amino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide | HCID 58062914 | — |
| Produkt | cis-N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide | HCID 58062933 | — |
Reaktionsschritte
The title compound, light yellow foam, MS: m/e=433.2 [(M+H)+], was prepared in accordance with the general method of example 10 from cis-N-(2-amino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (intermediate I) and 1,4-dibromo-2-butanol. The two diastereomers were not separated.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08404673B2 |
| Quelldatensatz | uspto-grants-2013_03 |
| ORD ID | ord-1df2402ed0fc418196bddc1714b2788e |
| Quellennotiz | uspto-grants-2013_03 |