HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → 3-(N-methyl-methoxycarbamoyl)-5-nitro benzoic acid allyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Edukt | 5-Nitro-isophthalic acid 1-(2,5-dioxo-pyrrolidin-1-yl) ester 3-allyl ester | HCID 22986099 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 3-(N-methyl-methoxycarbamoyl)-5-nitro benzoic acid allyl ester | HCID 20655861 | — |
Reaktionsschritte
A mixture of (7(b)) (2.00 g), N,O-dimethylhydroxylamine hydrochloride (0.62 g), triethylamine (0.86 ml) and dichloromethane (60 ml) was stirred at 5° for 30 min and then allowed to warm to ambient temperature and stirred for a further 16 h. The mixture was poured onto a flash column and eluted with ethyl acetate/hexane (40:60)to give 3-(N-methyl-methoxycarbamoyl)-5-nitro benzoic acid allyl ester (7(c)) as a yellow oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06232338B1 |
| Quelldatensatz | uspto-grants-2001_05 |
| ORD ID | ord-fa852f342c674df3a82b19d74e6f6a87 |
| Quellennotiz | uspto-grants-2001_05 |