HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-(Trifluoromethoxy)phenylboronic acid → (4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1-(4-trifluoromethoxy-phenyl)-1H-indol-2-yl]-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-(Trifluoromethoxy)phenylboronic acid | HCID 2734386 | — |
| Edukt | (4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]methanone | HCID 11603838 | — |
| Produkt | (4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1-(4-trifluoromethoxy-phenyl)-1H-indol-2-yl]-methanone | HCID 16739415 | — |
Reaktionsschritte
In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (intermediate 1) and 4-trifluoromethoxybenzene boronic acid. The title compound was obtained in 84% yield as white foam. MS (m/e): 566.4 (MH+, 100%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07745479B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-89230d3715734d678f0708c2cb97492d |
| Quellennotiz | uspto-grants-2010_06 |