Trifluoroacetic acid → 2-(4-{3-[1-(3,4-Dimethyl-benzyl)-2-oxo-imidazolidin-4-yl]-propyl]-phenoxy}-2-methyl-propionic acid

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A solution of 2-(4-{3-[1-(3,4-dimethyl-benzyl)-2-oxo-imidazolidin-4-yl]-propyl}-phenoxy)-2-methyl-propionic acid tert-butyl ester (0.051 g, 0.106 mmol) in CH2Cl2 (3 mL) was treated with trifluoroacetic acid (0.5 mL) and stirred at room temperature under N2 for 5 h. The solvent removed in vacuo to give crude acid that was purified by flash chromatography using 94:6 CH2Cl2:MeOH to afford 0.011 g (24%) 2-(4-{3-[1-(3,4-dimethyl-benzyl)-2-oxo-imidazolidin-4-yl]-propyl}-phenoxy) -2-methyl-propionic acid. MS (ES+) Calc'd for C25H33N2O4 (M+1) 425. Found m/z 425 (100%). 1H NMR.

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