Racemic 2-[5-Methyl-2-(3-piperidin-3-ylpropylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide → Racemic 2-{5-Chloro-2-[3-(2-isopropylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide

Beteiligte Stoffe

Reaktionsschritte

Using the method of racemic 2-[5-methyl-2-(3-piperidin-3-ylpropylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide, the title compound is synthesized from 2-(2,5-dichloropyrimidin-4-yl)-benzo[b]thiophene-4-carboxylic acid cyclopropylamide and racemic 4-(3-aminopropyl)-3-isopropylpiperazine-1-carboxylic acid tert-butyl ester and isolated as a solid. ES+(m/z) 513 (35Cl) and 515 (37Cl) [M+H].

Herkunft & Nachweise