HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Propanesulfonyl chloride → [5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-[4-(propane-2-sulfonyl)-piperazin-1-yl]-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Propanesulfonyl chloride | HCID 82408 | — |
| Edukt | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Edukt | 1-(Isopropylsulfonyl)piperazine | HCID 22562851 | — |
| Edukt | [5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone | HCID 68538245 | — |
| Produkt | [5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-[4-(propane-2-sulfonyl)-piperazin-1-yl]-methanone | HCID 68534115 | 87% |
Reaktionsschritte
The title compound was synthesized in analogy to example 1, from 5-(4-isopropyl-piperazine-1-carbonyl)-1H-indole-2-carboxylic acid hydrochloride (example 1, intermediate b) and 1-(1-methylethylsulfonyl)piperazine (prepared in analogy to WO2003064413 using isopropylsulfonyl chloride and tert-butyl 1-piperazinecarboxylate) to afford the desired product as a light-brown solid (87%). MS (ISP): 490.3 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07648979B2 |
| Quelldatensatz | uspto-grants-2010_01 |
| ORD ID | ord-ccd7b355e89e409f937b6791ba6e6967 |
| Quellennotiz | uspto-grants-2010_01 |