Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | Benzyl Bromide | HCID 7498 | — |
| Edukt | Potassium Hydroxide | HCID 14797 | — |
| Edukt | 2-Methylglyceric acid | HCID 560781 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | Benzyl 3-hydroxy-2,2-dimethylpropanoate | HCID 18922595 | — |
Reaktionsschritte
Add potassium hydroxide (486.7 mmol, 32.1 g) over a solution of 2,3-dihydroxy-2-methyl-propionic acid (423.2 mmol, 50 g) in 300 mL of DMF. Stir the solution for 1 hour at 100° C., then add benzyl bromide. Stir the solution overnight. Cool the mixture and dilute with ethyl acetate. Wash organic layer with water. Wash aqueous layer with ethyl acetate several times. Combine organic layers and dry over sodium sulfate, filter and concentrate under reduced pressure.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US07652015B2 |
|---|
| Quelldatensatz | uspto-grants-2010_01 |
|---|
| ORD ID | ord-47c92e3d87394898bcbcff1ac92ca457 |
|---|
| Quellennotiz | uspto-grants-2010_01 |
|---|
