Potassium Carbonate → Diethyl [4-(7-ethoxymethyl-3-methylxanthin-1-yl)butyl]phosphonate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

44.8 g (0.2 mol) of 7-ethoxymethyl-3-methylxanthine were suspended in 500 ml of DMF, treated with 55 g (0.24 mol) of diethyl 4-chlorobutane-phosphonate and 50 g (0.32 mol) of activated potassium carbonate and heated at 70° C. for 4 hours and filtered, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate. filtered again and crystallized from diisopropyl ether.

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