HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Thionyl Chloride → {4-[2-(4-Fluoro-phenyl)ethyl]piperazin-1-yl}isoquinolin-3-ylmethanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Thionyl Chloride | HCID 24386 | — |
| Edukt | Isoquinoline-3-carboxylic acid | HCID 124656 | — |
| Edukt | 1-(2-(4-Fluorophenyl)ethyl)piperazine | HCID 11254522 | — |
| Edukt | Isoquinoline-3-carbonyl chloride | HCID 22064853 | — |
| Produkt | {4-[2-(4-Fluoro-phenyl)ethyl]piperazin-1-yl}isoquinolin-3-ylmethanone | HCID 44215581 | — |
Reaktionsschritte
Analogously to Example 3, firstly isoquinoline-3-carboxylic acid is reacted with thionyl chloride, and the resultant isoquinoline-3-carbonyl chloride is reacted with 1-[2-(4-fluorophenyl)ethyl]piperazine, giving {4-[2-(4-fluoro-phenyl)ethyl]piperazin-1-yl}isoquinolin-3-ylmethanone.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07329749B2 |
| Quelldatensatz | uspto-grants-2008_02 |
| ORD ID | ord-12574c840ca043dda608e9a7b995a546 |
| Quellennotiz | uspto-grants-2008_02 |