Triethylamine → N-(3-(6-chloro-4-iodopyridin-2-ylamino)cyclohexyl)-2-(1,3-dioxoisoindolin-2-yl)ethanesulfonamide

Beteiligte Stoffe

Reaktionsschritte

To a solution of Example 145a (280 mg, 0.8 mmol) in CH2Cl2 (10 mL) was added triethylamine (110 mg, 1 mmol) and followed by 2-(1,3-dioxoisoindolin-2-yl)ethanesulfonyl chloride (262 mg, 0.95 mmol). The mixture was stirred at room temperature overnight. The reaction mixture was concentrated and the residue was purified by flash chromophatography (EtOAc/hexanes=1:4) to give the title compound. Yield: 180 mg (32%). MS (DCI/NH3) m/z 589 (M+H)+.

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