Diisobutylamine → 2-[2-(2,2-Dimethylpropanoyl)-5-methoxy-1-benzofuran-3-yl]-N,N-diisobutylacetamide

https://huagongshe.com/de/reaction/2103753

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Diisobutylamine	HCID 8085	—
Edukt	1-Hydroxybenzotriazole	HCID 75771	—
Edukt	Diisopropylethylamine	HCID 81531	—
Edukt	[2-(2,2-Dimethylpropanoyl)-5-methoxy-1-benzofuran-3-yl]acetic acid	HCID 57804476	—
Lösungsmittel	1,2-Dichloroethane	HCID 11	—
Lösungsmittel	Dimethylformamide	HCID 6228	—
Produkt	2-[2-(2,2-Dimethylpropanoyl)-5-methoxy-1-benzofuran-3-yl]-N,N-diisobutylacetamide	HCID 11350154	—

Reaktionsbedingungen

Temperatur	40 °C

Reaktionsschritte

Dissolve a mixture of 17 mg [2-(2,2-dimethylpropanoyl)-5-methoxy-1-benzofuran-3-yl]acetic acid from the Step B Example 1 and 18.5 mg HOBt in 1 mL dry DMF. Add 15.4 μL di-i-butylamine followed by 23.0 mg EDC and 35 μL DIEA. This solution was heated at 40° C. for 2 hours. It was purified directly on RP-HPLC using 65-100% MeCN gradient. The fractions containing pure product were pooled and lyophilized to give the title compound. LC-MS: 4.42 min. (m/Z=318.2, 402.2, 424.2).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07576122B2
Quelldatensatz	uspto-grants-2009_08
ORD ID	ord-85e94175ff08464a9636651522046be1
Quellennotiz	uspto-grants-2009_08