1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 3-acetoxy-N-(1-methyl-1-phenylethyl)benzamide

Beteiligte Stoffe

Reaktionsschritte

In a similar manner to Step 1 of Example 137, 3-acetoxybenzoic acid (7.92 g, 44.0 mmol) was dissolved in DMF (45 mL), and the solution was treated with EDCI (12.7 g, 66.0 mmol), HOBT monohydrate (3.37 g, 22.0 mmol) and cumylamine (14.2 mL, 96.8 mmol), followed by purification by slurry using diisopropylether to obtain 3-acetoxy-N-(1-methyl-1-phenylethyl)benzamide (9.57 g, yield 73%).

Herkunft & Nachweise