HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(Tri-n-butylstannyl)thiophene → 7-Amino-4-(thiophen-2-yl)isoindolinone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(Tri-n-butylstannyl)thiophene | HCID 2779373 | — |
| Edukt | 7-Amino-4-bromo-2,3-dihydroisoindol-1-one | HCID 19701932 | — |
| Katalysator | HCID 178418476 | HCID 178418476 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 7-Amino-4-(thiophen-2-yl)isoindolinone | HCID 68492478 | 54% |
Reaktionsschritte
In a similar manner to Step 1 of Example 10, 7-amino-4-bromoisoindolinone (404 mg, 1.78 mmol) was dissolved in THF (20 mL), and the solution was treated with 2-(tributylstannyl)thiophene (1.13 mL, 3.56 mmol) and bis(triphenylphosphine)dichloropalladium (100 mg, 0.142 mmol), followed by purification by preparative thin-layer chromatography (chloroform/methanol=12/1) to obtain 7-amino-4-(thiophen-2-yl)isoindolinone (220 mg, yield 54%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07745641B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-4bfbc436ac3f44c8b9a69949eb1f4ac1 |
| Quellennotiz | uspto-grants-2010_06 |