HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 215915Erstellt: 24. Oktober 2026
Diethyl (3-aminopropyl)phosphonate → Diethyl 3-(4-(1-(2-(Dimethylamino)-6-methoxybenzyl)piperidin-4-ylamino)quinazolin-2-ylamino)propylphosphonate
https://huagongshe.com/de/reaction/215915
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Diethyl (3-aminopropyl)phosphonate | HCID 78113 | — |
| Edukt | 2-Chloro-N-(1-(2-(dimethylamino)-6-methoxybenzyl)piperidin-4-yl)quinazolin-4-amine | HCID 58006255 | — |
| Lösungsmittel | 1-Butanol | HCID 263 | — |
| Produkt | Diethyl 3-(4-(1-(2-(Dimethylamino)-6-methoxybenzyl)piperidin-4-ylamino)quinazolin-2-ylamino)propylphosphonate | HCID 58006204 | — |
Reaktionsschritte
Following General Procedure D, Compound 47 (50 mg, 0.12 mmol) and diethyl 3-aminopropylphosphonate (69 mg, 0.36 mmol) in n-BuOH (3 mL) were heated to 117° C. for 24 h with a reflux condenser. The product (Compound 81) was purified by preparative silica gel TLC plate 1000μ using 5% (7N NH3-MeOH) and 95% CH2Cl2 solution as eluent.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08193203B2 |
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| Quelldatensatz | uspto-grants-2012_06 |
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| ORD ID | ord-ce4843057c1b49bcb9d1098f304d04c1 |
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| Quellennotiz | uspto-grants-2012_06 |
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