HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Lithium amide → 1-Methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Lithium amide | HCID 24532 | — |
| Edukt | ethyl 1-methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxylate | HCID 15294535 | — |
| Produkt | 1-Methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxamide | HCID 15294532 | 78% |
Reaktionsschritte
Prepared from ethyl 1-methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxylate and lithium amide as described in Example 18. After evaporation of excess ammonia, the residue is treated with ice water. The insoluble material is filtered and washed with water, then recrystallized from ethyl acetate-hexane. Yield 78%; mp 151°-154° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05424329 |
| Quelldatensatz | uspto-grants-1995_06 |
| ORD ID | ord-a14145a8404a40248665186c7668a3e0 |
| Quellennotiz | uspto-grants-1995_06 |