tert-Butylsulfinamide, (S)-(-)- → (S)-N-(5-bromo-6-(((tert-butylsulfinyl)imino)methyl)pyridin-2-yl)acetamide

Beteiligte Stoffe

Reaktionsschritte

Copper(II) sulfate (anhydrous 2.8 g, 17.2 mmol) was added to a solution of N-(5-bromo-6-formylpyridin-2-yl)acetamide (crude material, assume 8.6 mmol) and (S)-2-methylpropane-2-sulfinamide (1.2 g, 9.4 mmol) in DCM (30 ml). The suspension was stirred overnight at room temperature. The reaction was filtered and washed with DCM (3×20 ml). The filtrate was concentrated. The crude product was purified by flash column (30% EtOAc/Hexanes). MS (m/z) 346.1 [M+H]+.

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