Ethyl piperidine-2-carboxylate → N-(2,4-dichloro-6-fluorobenzothiazol-7-yl)-perhydroimidazo[1,5-a]pyridine-1,3-dione

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Reaktionsschritte

2.6 g Ethyl piperidine-2-carboxylate was added to a solution of 4.2 g 2,4-dichloro-6-fluoro-7-isocyanato-benzothiazole in 50 ml tetrahydrofuran. The mixture was heated for 5 hours under reflux. After cooling, the solvent was removed in vacuo and the residue recrystallised several times from ethyl acetate. Yield: 2.5 g=42% of theory m.p.: 168°-170° C.

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