HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 217446Erstellt: 24. Oktober 2026
[(4-Isobutylphenyl)ethynyl](trimethyl)silane → 5-Fluoro-7-((4-isobutylphenyl)ethynyl)-2H-chromene-3-carbaldehyde
https://huagongshe.com/de/reaction/217446
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | [(4-Isobutylphenyl)ethynyl](trimethyl)silane | HCID 58438693 | — |
| Edukt | 5-fluoro-3-formyl-2H-chromen-7-yl trifluoromethanesulfonate | HCID 86657642 | — |
| Katalysator | Cupric Chloride | HCID 24014 | — |
| Katalysator | HCID 178418397 | HCID 178418397 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 5-Fluoro-7-((4-isobutylphenyl)ethynyl)-2H-chromene-3-carbaldehyde | HCID 58438685 | 23,8% |
Reaktionsschritte
To a solution of copper chloride (10 mg) and Pd(PPh3)4 (60 mg) in DMF (2 mL) were added [(4-isobutylphenyl)ethynyl](trimethyl)silane (288 mg) and 5-fluoro-3-formyl-2H-chromen-7-yl trifluoromethanesulfonate (340 mg) at room temperature, followed by stirring at 80° C. for 12 hours. The reaction liquid was concentrated and the residue was purified by silica gel column chromatography (CHCl3) to obtain 5-fluoro-7-[(4-isobutylphenyl)ethynyl]-2H-chromene-3-carbaldehyde (83 mg) as a yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US08193378B2 |
|---|
| Quelldatensatz | uspto-grants-2012_06 |
|---|
| ORD ID | ord-2d1d4fcb25d646269e27f1f81a42f442 |
|---|
| Quellennotiz | uspto-grants-2012_06 |
|---|
