HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Picolinic acid → Diethyl 2-(5-bromopyridin-2-yl)malonate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Picolinic acid | HCID 1018 | — |
| Edukt | Diethyl Malonate | HCID 7761 | — |
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | 5-Bromo-2-iodopyridine | HCID 593690 | — |
| Katalysator | Copper | HCID 23978 | — |
| Katalysator | Copper iodide | HCID 83717 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | Diethyl 2-(5-bromopyridin-2-yl)malonate | HCID 59238270 | — |
Reaktionsschritte
2-(5-Bromo-pyridin-2-yl)-malonic acid diethyl ester (XXXVI) is prepared by copper-catalyzed reaction with malonic acid diethyl ester. The reaction is typically performed by mixing XXXV with malonic acid diethyl ester, copper iodide, cesium carbonate, and pyridine-2-carboxylic acid in 1,4-dioxane and heating to 70 degrees Celsius for 24 hours under nitrogen atmosphere.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08202866B2 |
| Quelldatensatz | uspto-grants-2012_06 |
| ORD ID | ord-4a0d2e13f2e54af8857cd02a2ed3add9 |
| Quellennotiz | uspto-grants-2012_06 |