HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl 4-piperidinecarboxylate → Ethyl 1-(5-amino-6-chloroquinolin-2-yl)piperidine-4-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Edukt | 2,6-Dichloroquinolin-5-amine | HCID 24820374 | — |
| Produkt | Ethyl 1-(5-amino-6-chloroquinolin-2-yl)piperidine-4-carboxylate | HCID 69320002 | 71,8% |
Reaktionsschritte
Prepared according to the method of example 30, using 2,6-dichloroquinolin-5-amine (Example 1(d)) (800 mg) and 4-piperidinecarboxylic acid, ethyl ester (1.8 g). Purification (SiO2, miethanol:dichloromethane 1:99 as eluant) gave the sub-title compound as a solid (900 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07408065B2 |
| Quelldatensatz | uspto-grants-2008_08 |
| ORD ID | ord-5e1c6f6da2c841d0bdbd637d4977daf3 |
| Quellennotiz | uspto-grants-2008_08 |