2-Nitropropane → 5-Bromo-3-(2-methyl-2-nitropropyl)indole

Beteiligte Stoffe

Reaktionsschritte

5-Bromogramine, 60.0 g., 165 g. of 2-nitropropane, and 10.5 g. of sodium hydroxide pellets were caused to react under the conditions of Procedure 67C. The product was recovered as a dark syrup-like liquid from which the crystalline product was obtained by dissolving in IPr2O. The crystalline material was recrystallized from IPr2O to yield 48.6 g. of tan crystalline product, m.p. 106°-109°. The structure was confirmed by examination of the NMR spectrum.

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