HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
6-(benzyloxy)-1H-indole → (6-Benzyloxy-1H-indol-3-yl)-(2,2,3,3-tetramethyl-cyclopropyl)-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 6-(benzyloxy)-1H-indole | HCID 260804 | — |
| Edukt | 2,2,3,3-Tetramethylcyclopropane-1-carbonyl chloride | HCID 11041002 | — |
| Edukt | HCID 178418443 | HCID 178418443 | — |
| Katalysator | Zincchloride | HCID 3007855 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | (6-Benzyloxy-1H-indol-3-yl)-(2,2,3,3-tetramethyl-cyclopropyl)-methanone | HCID 24823780 | 64,4% |
Reaktionsschritte
A mixture of 6-benzyloxyindole (Lancaster, 2.0 g, 9.0 mmol), ethylmagnesium bromide (1.0 M solution in THF, 11 mL, 11 mmol), zinc chloride (1.0 M solution in Et2O, 11 mL, 11 mmol) and the product of Example 1A (13.4 mmol) in 30 mL of dichloromethane was processed as described in Example 1B to provide the title compound (2.0 g, 5.8 mmol, 64% yield). MS (DCI/NH3) m/z 348 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07560481B2 |
| Quelldatensatz | uspto-grants-2009_07 |
| ORD ID | ord-0200d6e4d77a485a8470521c8d7eb478 |
| Quellennotiz | uspto-grants-2009_07 |