HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
p-(1-Piperazinyl)phenol → (3-(2-Fluorophenyl)-5-methylisoxazol-4-yl)(4-(4-hydroxyphenyl)piperazine-1-yl)methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | p-(1-Piperazinyl)phenol | HCID 92467 | — |
| Edukt | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Edukt | 3-(2-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid | HCID 6484101 | — |
| Edukt | HCID 178418300 | HCID 178418300 | — |
| Produkt | (3-(2-Fluorophenyl)-5-methylisoxazol-4-yl)(4-(4-hydroxyphenyl)piperazine-1-yl)methanone | HCID 66576944 | 77,2% |
Reaktionsschritte
In a similar manner as described in Example 1, by using dimethylformimide (15 mL), 3-(2-fluorophenyl)-5-methylisoxazol-4-carboxylic acid (407 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol), hydroxybenzotriazole (299 mg, 2.21 mmol) and 4-(piperazine-1-yl)phenol (424 mg, 1.84 mmol), a white solid required compound (542 mg, 1.42 mmol, 77%) was obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09132126B2 |
| Quelldatensatz | uspto-grants-2015_09 |
| ORD ID | ord-b7b3e7ebac1a4864a4f7cd3666214928 |
| Quellennotiz | uspto-grants-2015_09 |