HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Aminobenzophenone → (2S,4S)-1-[[N-[4-[N-(4-benzoylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Aminobenzophenone | HCID 14346 | — |
| Edukt | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| Produkt | (2S,4S)-1-[[N-[4-[N-(4-benzoylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57756805 | 14,8% |
Reaktionsschritte
In a similar manner to Example 63, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 4-aminobenzophenone (67.0 mg) were used to obtain (2S,4S)-1-[[N-[4-[N-(4-benzoylphenyl)amino]carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (11.5 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07560569B2 |
| Quelldatensatz | uspto-grants-2009_07 |
| ORD ID | ord-e3f7ebd9c7b7443bad8bd38312da6939 |
| Quellennotiz | uspto-grants-2009_07 |