Ethanol → 2-Hydroxymethyl-5-methylpyrazine-4-oxide

HRID 2286699

Reaktionsgleichung

Reaktionsgleichung von HRID 2286699
[C:1]([C:4]1[CH:9]=[N+:8]([O-:10])[C:7]([CH3:11])=[CH:6][N:5]=1)(O)=[O:2].B#B.C(O)C.C([O-])([O-])=O.[K+].[K+]>COCCOCCOC.O1CCCC1>[OH:2][CH2:1][C:4]1[CH:9]=[N+:8]([O-:10])[C:7]([CH3:11])=[CH:6][N:5]=1

Komponenten

7

Edukt 4

HCID 702EthanolHCID 11430Potassium CarbonateHCID 5310993AcipimoxHCID 6328200Diboron

Produkt 1

HCID 130230052-Hydroxymethyl-5-methylpyrazine-4-oxideAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 8150DiglymeLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Method B--To a solution of 2-carboxy-5-methyl-pyrazine-4-oxide (1.5 g) in diethylene glycol dimethyl ether (80 ml) addition was made at 0° C. under an atmosphere of nitrogen of a solution (1 M) of diborane in tetrahydrofuran (30 ml). To the reaction mixture maintained for 3 hours at 0° C. and 1 hour at room temperature, cautious addition was made of ethanol (50 ml) and then of a 0.5 M solution of alcoholic potash (25 ml). The resultant solution after evaporation at reduced pressure was taken up with chloroform which, on evaporation to dryness, gave 1.2 g of 2-hydroxymethyl-5-methyl-pyrazine-4-oxide.

Aufarbeitung

  1. additioncautious addition
  2. customThe resultant solution after evaporation at reduced pressure
  3. customwas taken up with chloroform which, on evaporation to dryness

Quellen und Nachweise

ORD-Eintrag
ord-97dcf43bbb0f44b29e1906d04cb7bd67
Quelldatensatz
uspto-grants-1981_05
Patentnummer
US04267327

Verknüpfte Notizen

Wird geladen…