HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → 4-(Dimethylamino)piperidine dihydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Dimethylamine, hydrochloride | HCID 10473 | — |
| Edukt | Triacetoxyborohydride | HCID 2724942 | — |
| Edukt | 4-Boc-piperidinone | HCID 22318161 | — |
| Edukt | Tert-butyl 4-(dimethylamino)piperidine-1-carboxylate | HCID 22591376 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | 4-(Dimethylamino)piperidine dihydrochloride | HCID 22591440 | — |
Reaktionsschritte
Dimethylamine hydrochloride (430 mg) was added to a methylene chloride (10 ml) solution containing 4-(tert-butoxycarbonyl)piperidone (1.0 g), and under ice-cooling, triethylamine (0.84 ml) and triacetoxyborohydride (1.17 g) were further added thereto, and the mixture was stirred at room temperature for 3 hours to undergo reaction, thereby obtaining N-tert-butoxycarbonyl-4-dimethylaminopiperidine. This compound was acid-treated with hydrochloric acid to obtain 4-(dimethylamino)piperidine.dihydrochloride.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06849622B2 |
| Quelldatensatz | uspto-grants-2005_02 |
| ORD ID | ord-2a621ec232ee49fcbfb7856de2c1ed48 |
| Quellennotiz | uspto-grants-2005_02 |