HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzoic Acid → N-(piperidin-4-yl)benzamide hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzoic Acid | HCID 243 | — |
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Edukt | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Edukt | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | N-(piperidin-4-yl)benzamide hydrochloride | HCID 21942082 | — |
Reaktionsschritte
A mixture comprising 4-amino-1-(tert-butoxycarbonyl)piperidine (700 mg), benzoic acid (512 mg), 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (804 mg), 1-hydroxybenzotriazole (567 mg) and N,N-dimethylformamide (10 ml) was stirred at room temperature for 16 hours to undergo reaction, and the resulting compound was acid-treated with hydrochloric acid to obtain 4-(benzoylamino)piperidine.hydrochloride.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06849622B2 |
| Quelldatensatz | uspto-grants-2005_02 |
| ORD ID | ord-896dc73da64e41a0937ff5ca2ca0765c |
| Quellennotiz | uspto-grants-2005_02 |