HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Nabumetone → 4-(5-Bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Nabumetone | HCID 4409 | — |
| Edukt | 1-(5-Bromo-6-methoxynaphthalen-2-yl)ethan-1-one | HCID 622178 | — |
| Produkt | 4-(5-Bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one | HCID 70179405 | — |
Reaktionsschritte
New process for the synthesis of the antiinflammatory drug known as nabumetone that consists in reacting 2-acetyl-5-bromo-6-methoxynaphthalene with an alkyl acetate in presence of an alkaline alcoholate to get 4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one that by catalytic hydrogenation in a polar solvent and in presence of a base gives 4-(6-methoxy-2-naphthyl)butan-2-one known as nabumetone.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | USRE037813E1 |
| Quelldatensatz | uspto-grants-2002_08 |
| ORD ID | ord-e8af2dc2fa244f8c835572dcc4d6e971 |
| Quellennotiz | uspto-grants-2002_08 |