HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Isopropanol → 4-[3-[4-(6-Fluoro1,2-benzisoxazol-3-yl)-piperidinyl]-2-hydroxy-1-propoxy]phenyl methyl ether
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Isopropanol | HCID 3776 | — |
| Edukt | 3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole | HCID 849421 | — |
| Edukt | 2,3-Epoxypropyl4-methoxyphenyl ether | HCID 19964422 | — |
| Produkt | 4-[3-[4-(6-Fluoro1,2-benzisoxazol-3-yl)-piperidinyl]-2-hydroxy-1-propoxy]phenyl methyl ether | HCID 18467257 | — |
Reaktionsschritte
A mixture of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine (4.4 g, 20 mmol) and 2,3-epoxypropyl-4-methoxyphenyl ether (3.7 g, 20.5 mmol) in isopropyl alcohol (80 ml) was heated to reflux for 2 hours. The mixture was cooled and the crystals were collected to yield 6.81 g (85%), m.p.=134°-135° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05597842 |
| Quelldatensatz | uspto-grants-1997_01 |
| ORD ID | ord-3937fdb9a4334a1db1b14b3fbdac0b26 |
| Quellennotiz | uspto-grants-1997_01 |