HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Lithium Hydroxide → 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Lithium Hydroxide | HCID 3939 | — |
| Edukt | 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester | HCID 69206346 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Lösungsmittel | MeOH tetrahydrofuran | HCID 21899815 | — |
| Produkt | 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid | HCID 69208103 | 81,4% |
Reaktionsschritte
A solution of 5-(3-trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester (0.234 g, 0.712 mmol) in THF:MeOH (4:1, 5 mL) was treated with LiOH (0.150 g, 3.564 mmol) in 1.5 mL of water by the general procedure C to give 0.182 g of 5-(3-trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid. LCMS: 316 (M+2)+
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07459472B2 |
| Quelldatensatz | uspto-grants-2008_12 |
| ORD ID | ord-7492f68c66fc4f699500508db3bfc5dc |
| Quellennotiz | uspto-grants-2008_12 |