HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(S)-3-Methylpiperidine → ((R)-3-Methyl-piperidin-1-yl)-[8-(1H-pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl]-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (S)-3-Methylpiperidine | HCID 641100 | — |
| Edukt | 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid | HCID 58203883 | — |
| Produkt | ((R)-3-Methyl-piperidin-1-yl)-[8-(1H-pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl]-methanone | HCID 58204081 | — |
Reaktionsschritte
Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with (S)-3-methylpiperidine (1.2 equiv) to give 163 (13.8 mg, M+1 395.1)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08263633B2 |
| Quelldatensatz | uspto-grants-2012_09 |
| ORD ID | ord-e30fafe32ee24ac5aad3b9f73e200df9 |
| Quellennotiz | uspto-grants-2012_09 |