HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzoyl chloride → (3-Benzoylamino-propyl)-carbamic acid tert-butyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzoyl chloride | HCID 7412 | — |
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | tert-Butyl (3-aminopropyl)carbamate | HCID 2735700 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | (3-Benzoylamino-propyl)-carbamic acid tert-butyl ester | HCID 10492863 | — |
Reaktionsschritte
(3-Amino-propyl)-carbamic acid tert-butyl ester (1.6 g) was treated with benzoyl chloride (1.1 eq.) and triethylamine (1.5 eq) in methylene chloride (50 mL). The reaction mixture was washed with 1 N HCl, sat, NaHCO3, and sat NaCl and the solvent removed to give product. LC-MS showed the product had the expected M+H+ of 279.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08268822B2 |
| Quelldatensatz | uspto-grants-2012_09 |
| ORD ID | ord-dd27532696644c2181c9445e2b220bfc |
| Quellennotiz | uspto-grants-2012_09 |