1-Fluoro-4-methanesulfonyl-2-nitrobenzene → 2-Fluoro-5-(methylsulfonyl)aniline

Beteiligte Stoffe

Reaktionsschritte

A mixture of 4-fluoro-3-nitrophenyl methyl sulfone (Acros; 1.00 g; 4.56 mmol) and PtO2 (100 mg) in MeOH (150 ml) was placed in a PARR reactor and treated with a pressure of 20 atm of hydrogen for 3 hours. The reaction mixture was filtered through Celite and the filtrate was concentrated to dryness affording the title compound (964 mg) as a dark green oil.

Herkunft & Nachweise