Dimethyl Sulfate → Benzoic acid, 2-(methylamino)-3-nitro-, methyl ester

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

9.8 g (50 mmol) of 4-methylamino-3-nitro-benzoic acid are treated in 50 ml of dimethyl formamide (DMF) with K2CO3 (14 g). 5 ml of dimethyl sulphate are added dropwise to this mixture over 10 minutes with stirring. It is stirred for 15 minutes and heated for 0.5 hours at 60° C. After cooling, it is diluted with water, the precipitated solids are filtered off, washed with water and dried. Yield: 9.8 g (93%); M.Pt.: 138-140° C.

Herkunft & Nachweise