HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1H-1,2,4-Triazole → (2R,3R)-2-(2,4-Difluorophenyl)-3-[6-methoxy-9(9H)-purinyl]-1-(1H-1,2,4-triazol-1-yl)-2-butanol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1H-1,2,4-Triazole | HCID 9257 | — |
| Edukt | (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl] oxirane | HCID 18657628 | — |
| Produkt | (2R,3R)-2-(2,4-Difluorophenyl)-3-[6-methoxy-9(9H)-purinyl]-1-(1H-1,2,4-triazol-1-yl)-2-butanol | HCID 54133618 | 77,4% |
Reaktionsschritte
Using 1H-1,2,4-triazole (74 mg) and (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl]oxirane (183 mg), Compound 47 (171 mg) was obtained as colorless prisms by the same way as in Example 1.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05495024 |
| Quelldatensatz | uspto-grants-1996_02 |
| ORD ID | ord-198a67c4a6f14f15879b6f221928542f |
| Quellennotiz | uspto-grants-1996_02 |