HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 243598Erstellt: 24. Oktober 2026
Diethylamine → methyl(2S)-3,3-dimethyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxoimidazolidin-1-yl}butanoate
https://huagongshe.com/de/reaction/243598
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Diethylamine | HCID 8021 | — |
| Edukt | Bis(4-nitrophenyl) carbonate | HCID 78756 | — |
| Edukt | methyl(2S)-2-[(2-{[(9H-fluoren-9-ylmethoxy)Carbonyl][(1-methyl-1H-benzimidazol-2-yl)methyl]amino}ethyl)amino]-3,3-dimethylbutanoate | HCID 66891668 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Lösungsmittel | 1,1-Dichloroethane | HCID 6365 | — |
| Produkt | methyl(2S)-3,3-dimethyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxoimidazolidin-1-yl}butanoate | HCID 66890629 | 65,2% |
Reaktionsschritte
A solution of the product of Example 148D (0.19 g) in N,N-dimethylformamide (3.5 mL) was treated with diethylamine (0.35 mL), stirred at 25° C. for 1.5 hours and concentrated. A solution of the residue in dichloroethane (7 mL) was treated with bis-(p-nitrophenyl) carbonate (0.128 g, 1.2 equivalents), stirred at 60° C. for 16 hours and concentrated. The residue was chromatographed on silica gel, eluting with ethyl acetate:dichloromethane (3:2) to give 80 mg (64%) of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08653141B2 |
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| Quelldatensatz | uspto-grants-2014_02 |
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| ORD ID | ord-f275c48d35fd4f29a700320587dd4070 |
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| Quellennotiz | uspto-grants-2014_02 |
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