HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Piperidine → 3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydroindole-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Piperidine | HCID 8082 | — |
| Edukt | 3-Methyl-1H-indole-2-carbaldehyde | HCID 277260 | — |
| Edukt | Oxindole | HCID 321710 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydroindole-2-one | HCID 54160725 | — |
Reaktionsschritte
A mixture of 2-oxindole (133 mg), 3-methylindole-2-carbaldehyde (190 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (10 mg) in ethanol was held in a sealed tube at 95° C. for 4 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven to give 3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydroindole-2-one.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06855730B2 |
| Quelldatensatz | uspto-grants-2005_02 |
| ORD ID | ord-d008e4a25a0f41618e2f339428d329a6 |
| Quellennotiz | uspto-grants-2005_02 |