HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Chloroethyl Isothiocyanate → 2-Chloro-4-(2-thiazolinylamino)benzoic acid methyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Chloroethyl Isothiocyanate | HCID 138661 | — |
| Edukt | Methyl 4-Amino-2-chlorobenzoate | HCID 11839197 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-Chloro-4-(2-thiazolinylamino)benzoic acid methyl ester | HCID 69564628 | — |
Reaktionsschritte
A mixture of 4-amino-2-chlorobenzoic acid methyl ester (0.5 g) and 2-chloroethylisothiocyanate (0.26 mL) in THF (20 mL) was refluxed for 24 h. THF was distilled and the residue was purified by column chromatography (silica gel: eluent: hexane/EtOAc 3:1-1:1) to yield 2-chloro-4-(2-thiazolinylamino)benzoic acid methyl ester (74 mg). ESMS: m/z 271 (MH+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06855843B2 |
| Quelldatensatz | uspto-grants-2005_02 |
| ORD ID | ord-2a25a18e5f0c4c359bac4a1888fb1f0e |
| Quellennotiz | uspto-grants-2005_02 |