HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Water → 5-Fluoro-2-(4'-acetamido-3'-methylphenyl)benzothiazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Acetyl chloride | HCID 6367 | — |
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 4-(5-Fluoro-1,3-benzothiazol-2-yl)-2-methylaniline | HCID 396813 | — |
| Lösungsmittel | Chloroform | HCID 6212 | — |
| Produkt | 5-Fluoro-2-(4'-acetamido-3'-methylphenyl)benzothiazole | HCID 9882781 | — |
Reaktionsschritte
Acetyl Chloride (0.09g, 1.55 mmol) was added to a solution of 5-fluoro2-(4′-amino-3′-methylphenyl)benzothiazole (0.2 g, 0.78 mmol) in chloroform (5 ml) containing triethylamine (86 mg, 0.85 mmol). The resulting solution was stirred for 30 min, then poured into water (20 ml). The organic layer was removed, dried (Na2SO4) and evaporated. Recrystallisation from ethanol gave a white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06858633B1 |
| Quelldatensatz | uspto-grants-2005_02 |
| ORD ID | ord-ae5991969bc04edba7258ddf1b0edf6e |
| Quellennotiz | uspto-grants-2005_02 |