Dicyclohexylcarbodiimide → 1-[2-(Benzyloxycarbonylamino)propanoyl]-2,2-dimethyl-4-imidazolidinone

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a stirred, ice-cold solution of N-(benzyloxycarbonyl)alanine (6.7 g) and 2,2-dimethyl-4-imidazolidinone (3.42 g) in 100 ml of THF, a solution of DCC (6.2 g) in 50 ml of THF was added dropwise during 15 minutes. The suspension was stirred at 0° C. for 2 hours and at room temperature for an additional 2 hours. The insoluble material was filtered off. The solvent was evaporated under reduced pressure. Crystallization of the residue from isopropanol gave the title product as a white powder m.p. 170°-171° C.

Herkunft & Nachweise