HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 256821Erstellt: 23. Oktober 2026
Riluzole → 3(2H)-Benzothiazoleethanol, 2-imino-6-(trifluoromethoxy)-, monohydrobromide
https://huagongshe.com/de/reaction/256821
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Riluzole | HCID 5070 | — |
| Edukt | 2-Bromoethanol | HCID 10898 | — |
| Edukt | 3-(2-Hydroxyethyl)-2-imino-6-trifluoromethoxybenzothiazoline | HCID 3076252 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 3(2H)-Benzothiazoleethanol, 2-imino-6-(trifluoromethoxy)-, monohydrobromide | HCID 3076251 | — |
Reaktionsschritte
2-(2-Imino-6-trifluoromethoxy-3-benzothiazolinyl)ethanol may be prepared according to the following process: 2-amino-6-trifluoromethoxybenzothiazole (9.4 g) and 2-bromoethanol (10 g) in absolute ethanol (30 cc) are heated to boiling for 95 hours. The mixture is then cooled to a temperature in the region of 20° C. The precipitate formed is filtered off and washed with ethyl ether (100 cc). 2-(2-Imino-6-trifluoromethoxy-3-benzothiazolinyl)ethanol hydrobromide (6.4 g), m.p. 219° C., is obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US05260297 |
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| Quelldatensatz | uspto-grants-1993_11 |
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| ORD ID | ord-22f87acda8d64e5d9fdeebf053f554a8 |
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| Quellennotiz | uspto-grants-1993_11 |
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